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These forms vary greatly in severity and in the muscles most affected.

While most forms, like the chromosome 5-related form, affect mostly the proximal muscles, other forms exist that affect mostly the muscles (those farther away from the body’s center) — at least in the beginning. In chromosome 5-related SMA, the later the symptoms begin and the more SMN protein there is, the milder the course of the disease is likely to be.

Its deficiency is caused by genetic flaws (mutations) on chromosome 5 in a gene called The primary symptom of chromosome 5-related (SMN-related) SMA is weakness of the voluntary muscles.

The muscles most affected are those closest to the center of the body, such as those of the shoulders, hips, thighs and upper back.

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