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Therefore, it is recommended that bilastine is administered at least one hour before or no sooner than two hours after a meal [2, 10].
The maximum plasma concentration (220 ng/m L) of bilastine 20 mg was found 1.3 hours after administration, half time was 14.5 hours, and plasma protein binding was 84–90% .
In the fasting state bilastine is quickly absorbed, but the absorption is slowed when it is taken with food or fruit juice.
Therefore, it is recommended that bilastine is taken at least one hour before and no sooner than two hours after a meal.
In vivo studies in rats have demonstrated reduction in histamine-stimulated smooth muscular contraction, bronchospasms, endothelial permeability, and microvascular extravasation .