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In 1985, it was discovered that c GMP was able to directly activate the light-dependent response of rod ion channels by studying light-adapted retina of frogs.

CNG channels were also found in cone photoreceptors, chemo sensitive cilia of olfactory sensory neurons, and the pineal gland.

Initially discovered in the cells that make up the retina of the eye, CNG channels have been found in many different cell types across both the animal and the plant kingdoms.

CNG channels have a very complex structure with various subunits and domains that play a critical role in their function.

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