She would play a possible surrogate mother for Jeff and Audrey (Patrick Warburton and Megyn Price).
On May 31, 2006, she hosted the first annual VH1 Rock Honors.
Pressly was a producer, as well as a star, in the 2005 movie Death to the Supermodels.
She hosted the October 7, 2006, episode of Saturday Night Live.
She guest-starred on an episode of MADtv (season 11), playing Hillary Clinton in a parody of My Name Is Earl, "My Name Is Dubya", in which George W.
She is best known for playing Joy Turner on the NBC sitcom My Name Is Earl, for which she was nominated for two Emmy Awards (winning one) as well as a Golden Globe Award and a Screen Actors Guild Award.